Validation of Spectrophotometric Methods for the Assay of Zolmitriptan in Dosage Forms

The spectrophotometric methods M6, M7, M8 and M10 for the determination of Zolmitriptan in pure and dosage forms have been described in this paper. The present methods involve the determination of Zolmitriptan in pharmaceutical dosage at the given optimum conditions. The stock solution (1.0 mg/mL) of Zolmitriptan was prepared by dissolving 100 mg of the drug in 10.0 mL of methanol and made up to 100 mL with distilled water to get a clear solution. Appropriate volumes of this stock solution were diluted step wise to get the working standard solutions of concentrations 200 μg/mL for Methods-M8, M10,; 240 μg/mL for Method-M6; and 300 μg/mL for Method-M7 respectively. The proposed methods have the good sensitivity and higher λmax. Statistical analysis of the results showed that the proposed procedures have good precision and accuracy. The spectrophotometric methods based on reactivity of the functional groups of Zolmitriptan with various organic reagents to produce colored species of reasonable stability, paving the possibility for spectrophotometric determination of Zolmitriptan in pure and pharmaceutical formulations.